{"id":2441,"date":"2025-07-30T14:08:08","date_gmt":"2025-07-30T05:08:08","guid":{"rendered":"https:\/\/www.gxd.co.jp\/?p=2441"},"modified":"2025-10-08T11:51:48","modified_gmt":"2025-10-08T02:51:48","slug":"%e3%80%902025-7-26%e3%80%91%e5%bd%93%e7%a4%be%e4%bb%a3%e8%a1%a8%e3%81%ab%e3%82%88%e3%82%8b%e7%a9%ba%e9%96%93%e3%82%aa%e3%83%9f%e3%82%af%e3%82%b9%e7%a0%94%e7%a9%b6%e3%81%8c%e3%80%8enature-communication","status":"publish","type":"post","link":"https:\/\/www.gxd.co.jp\/?p=2441","title":{"rendered":"\u30102025.7.26\u3011\u300eNature Communications\u300f\u63b2\u8f09"},"content":{"rendered":"<p style=\"text-align: left;\">\u30102025.7.26\u3011\u5f53\u793e\u4ee3\u8868\u306b\u3088\u308b\u7a7a\u9593\u30aa\u30df\u30af\u30b9\u7814\u7a76\u300eNature Communications\u300f\u63b2\u8f09<\/p>\n<p style=\"text-align: left;\">\u5f53\u793e\u4ee3\u8868\u304c\u8457\u8005\u3092\u52d9\u3081\u305f\u7814\u7a76\u8ad6\u6587\u304c\u3001\u8457\u540d\u306a\u56fd\u969b\u5b66\u8853\u8a8c\u300eNature Communications\u300f\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u672c\u7814\u7a76\u306f\u3001\u975e\u7d50\u6838\u6027\u6297\u9178\u83cc\uff08NTM\uff09\u306b\u3088\u308b\u80ba\u611f\u67d3\u75c7\u306b\u5bfe\u3059\u308b\u5bbf\u4e3b\u514d\u75ab\u5fdc\u7b54\u306e\u30e1\u30ab\u30cb\u30ba\u30e0\u306b\u7126\u70b9\u3092\u5f53\u3066\u3066\u3044\u307e\u3059\u3002\u672c\u8ad6\u6587\u3067\u306f\u3001\u5f53\u793e\u4ee3\u8868\u306eWoong-Yang Park\u304c\u8457\u8005\u3092\u52d9\u3081\u3001\u5fe0\u5357\u5927\u5b66\uff08Chungnam National University\uff09\u306e\u30c1\u30e7\u30fb\u30a6\u30f3\u30ae\u30e7\u30f3\uff08Eun-Kyeong Jo\uff09\u6559\u6388\u304c\u5171\u540c\u8457\u8005\u3068\u3057\u3066\u53c2\u52a0\u3057\u307e\u3057\u305f\u3002\u307e\u305f\u3001\u30a4\u30fb\u30e8\u30f3\u30b8\u30e5\uff08Yeon-Ju Lee\uff09\u6c0f\u304c\u5171\u540c\u7b2c\u4e00\u8457\u8005\u3068\u3057\u3066\u7814\u7a76\u306b\u8ca2\u732e\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n<p style=\"text-align: left;\"><strong>\u7814\u7a76\u6982\u8981<\/strong><br \/>\n\u672c\u7814\u7a76\u3067\u306f\u3001\u30aa\u30fc\u30c8\u30d5\u30a1\u30b8\u30fc\u95a2\u9023\u30bf\u30f3\u30d1\u30af\u8cea\u3067\u3042\u308bATG7\u304c\u3001\u81ea\u7136\u514d\u75ab\u7d30\u80de\u306b\u304a\u3044\u3066\u975e\u7d50\u6838\u6027\u6297\u9178\u83cc\uff08NTM\uff09\u611f\u67d3\u306b\u5bfe\u3059\u308b\u9632\u5fa1\u306b\u91cd\u8981\u306a\u5f79\u5272\u3092\u679c\u305f\u3059\u3053\u3068\u304c\u660e\u3089\u304b\u306b\u306a\u308a\u307e\u3057\u305f\u3002\u7a7a\u9593\u30c8\u30e9\u30f3\u30b9\u30af\u30ea\u30d7\u30c8\u30df\u30af\u30b9\u89e3\u6790\u304a\u3088\u3073\u30de\u30a6\u30b9\u30fb\u7d30\u80de\u30e2\u30c7\u30eb\u3092\u7528\u3044\u305f\u5b9f\u9a13\u306b\u3088\u308a\u3001\u4ee5\u4e0b\u306e\u4e3b\u8981\u306a\u77e5\u898b\u304c\u5f97\u3089\u308c\u307e\u3057\u305f\uff1a<\/p>\n<ul style=\"text-align: left;\">\n<li>NTM\u60a3\u8005\u306e\u514d\u75ab\u7d30\u80de\u3067\u306f\u3001ATG7\u306e\u767a\u73fe\u304c\u4f4e\u4e0b\u3057\u3066\u3044\u308b<\/li>\n<li>ATG7\u6b20\u640d\u30e2\u30c7\u30eb\u3067\u306f\u3001\u83cc\u91cf\u306e\u5897\u52a0\u304a\u3088\u3073\u75c5\u7684\u306a\u708e\u75c7\u53cd\u5fdc\u304c\u9855\u8457\u306b\u898b\u3089\u308c\u308b<\/li>\n<li>\u597d\u4e2d\u7403\u306b\u3088\u308b\u514d\u75ab\u306e\u904e\u5270\u6d3b\u6027\u5316\u3068\u7d30\u80de\u6b7b\u304c\u8a98\u5c0e\u3055\u308c\u308b<\/li>\n<li>\u30de\u30af\u30ed\u30d5\u30a1\u30fc\u30b8\u306b\u304a\u3044\u3066\u3001\u98df\u80de\u2013\u30ea\u30bd\u30bd\u30fc\u30e0\u878d\u5408\u306e\u969c\u5bb3\u3068\u30df\u30c8\u30b3\u30f3\u30c9\u30ea\u30a2\u30b9\u30c8\u30ec\u30b9\u306e\u5897\u52a0\u304c\u78ba\u8a8d\u3055\u308c\u308b<\/li>\n<\/ul>\n<p style=\"text-align: left;\">\u3053\u308c\u3089\u306e\u77e5\u898b\u306f\u3001\u518d\u767a\u3092\u5f15\u304d\u8d77\u3053\u3059NTM\u80ba\u75be\u60a3\u306b\u5bfe\u3059\u308b\u65b0\u305f\u306a\u6cbb\u7642\u6226\u7565\u306e\u69cb\u7bc9\u306b\u5411\u3051\u305f\u91cd\u8981\u306a\u624b\u304c\u304b\u308a\u3068\u306a\u308b\u3082\u306e\u3067\u3059\u3002<\/p>\n<p style=\"text-align: left;\"><strong>[July 26, 2025] \u201cSpatial Omics Study by Geninus CEO Published in<\/strong>\u00a0<em><strong>Nature Communications<\/strong><\/em>\u201d<\/p>\n<p style=\"text-align: left;\">A study led by Geninus CEO Dr. Woong-Yang Park has been published in\u00a0<strong><em>Nature Communications<\/em><\/strong>, focusing on host immune response mechanisms against nontuberculous mycobacterial (NTM) pulmonary infections.Dr. Park served as the corresponding author. Prof.\u00a0<em><strong>Eun-Kyeong Jo<\/strong><\/em>\u00a0of Chungnam National University was co-senior author, and\u00a0<strong><em>Yeon-Ju Lee<\/em><\/strong>\u00a0contributed as a co-first author.<\/p>\n<p style=\"text-align: left;\"><strong>Study Overview<\/strong><br \/>\nThe study investigated the critical role of ATG7 in innate immune cells in defending against NTM infections, using spatial transcriptomics and in vivo\/in vitro models. Key findings include:<\/p>\n<ul style=\"text-align: left;\">\n<li>Reduced ATG7 expression in immune cells of NTM patients<\/li>\n<li>Elevated bacterial burden and pathological inflammation in ATG7-deficient models<\/li>\n<li>Neutrophil-driven immune dysregulation and cell death<\/li>\n<li>Impaired phagolysosomal fusion and mitochondrial stress in ATG7-deficient macrophages<\/li>\n<\/ul>\n<p style=\"text-align: left;\">These insights advance our understanding of immune regulation and may guide future therapeutic strategies for NTM lung disease.<\/p>\n<p style=\"text-align: left;\"><strong>Publication Info<\/strong><br \/>\n<strong>Title:\u00a0<em>ATG7 in innate immune cells is required for host defense against nontuberculous mycobacterial pulmonary infections<\/em><\/strong><br \/>\n<strong>Journal:\u00a0<em>Nature Communications<\/em><\/strong>\u00a0(2025)<\/p>\n<p style=\"text-align: left;\"><img decoding=\"async\" class=\"emoji\" role=\"img\" draggable=\"false\" src=\"https:\/\/s.w.org\/images\/core\/emoji\/16.0.1\/svg\/1f517.svg\" alt=\"\ud83d\udd17\" \/>\u00a0<a href=\"https:\/\/www.nature.com\/articles\/s41467-025-61791-1#author-information\" target=\"_new\" rel=\"noopener\">Read the full article<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>\u30102025.7.26\u3011\u5f53\u793e\u4ee3\u8868\u306b\u3088\u308b\u7a7a\u9593\u30aa\u30df\u30af\u30b9\u7814\u7a76\u300eNature Communications\u300f\u63b2\u8f09 \u5f53\u793e\u4ee3\u8868\u304c\u8457\u8005\u3092\u52d9\u3081\u305f\u7814\u7a76\u8ad6\u6587\u304c\u3001\u8457\u540d\u306a\u56fd\u969b\u5b66\u8853\u8a8c\u300eNature Communications\u300f\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002\u672c [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[76],"tags":[],"class_list":["post-2441","post","type-post","status-publish","format-standard","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/www.gxd.co.jp\/index.php?rest_route=\/wp\/v2\/posts\/2441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.gxd.co.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.gxd.co.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.gxd.co.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.gxd.co.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=2441"}],"version-history":[{"count":6,"href":"https:\/\/www.gxd.co.jp\/index.php?rest_route=\/wp\/v2\/posts\/2441\/revisions"}],"predecessor-version":[{"id":2649,"href":"https:\/\/www.gxd.co.jp\/index.php?rest_route=\/wp\/v2\/posts\/2441\/revisions\/2649"}],"wp:attachment":[{"href":"https:\/\/www.gxd.co.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=2441"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.gxd.co.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=2441"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.gxd.co.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=2441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}